| НСААF | 11/18 17:00 | 7 | Alma College Scots v Depauw Tigers | L | 32-17 | |
| НСААF | 11/11 18:07 | 1 | Wabash Little Giants v Depauw Tigers | W | 30-33 | |
| НСААF | 10/28 16:00 | 1 | Depauw Tigers v Kenyon Lords | W | 58-7 | |
| НСААF | 10/21 18:00 | 1 | Wittenberg Tigers v Depauw Tigers | W | 35-41 | |
| НСААF | 10/14 18:00 | 1 | Wooster v Depauw Tigers | W | 7-53 | |
| НСААF | 10/07 17:00 | 1 | Depauw Tigers v Denison Big Red | W | 17-6 | |
| НСААF | 09/30 17:00 | 1 | Oberlin Yeomen v Depauw Tigers | W | 7-66 | |
| НСААF | 09/23 17:00 | 1 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 28-7 | |
| НСААF | 09/16 17:00 | 1 | Depauw Tigers v Hiram Terriers | W | 49-0 | |
| НСААF | 09/09 17:00 | 1 | Depauw Tigers v Anderson Ravens | W | 68-19 | |
| НСААF | 09/02 23:00 | 1 | Rose Hulman Engineers v Depauw Tigers | W | 21-33 | |
| НСААF | 11/19 17:00 | 7 | Carnegie Mellon Tartans v Depauw Tigers | L | 45-14 |